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High Cholesterol

Cholesterol is an essential component of human cell membranes. It is transported via the bloodstream by small biochemical assemblies called lipoproteins. Lipoproteins are made of a lipid outer shell and contain protein on the inside. There are two types of lipoproteins that deliver cholesterol to the whole body: low-density lipoproteins (LDL) and high-density lipoproteins (HDL). Having healthy levels of both lipoprotein types is very important. LDL cholesterol is sometimes referred to as “bad cholesterol”; a high level of LDL leads to cholesterol build-up in the arteries. HDL cholesterol on the other hand is sometimes called “good cholesterol” because it carries cholesterol to the liver, where it is excreted from the body.

High cholesterol is caused by excessive cholesterol in the bloodstream. This condition does not bring about specific symptoms but increases the likelihood of plaque formation inside arteries and veins, which will eventually obstruct the normal blood flow. In the heart, this can cause an obstruction of the coronaries and trigger a heart attack, or lead to an occlusion of the carotid and thus damage the brain. Changing one’s lifestyle is therefore crucial especially with regard to healthy eating and sport.

In some cases high cholesterol is a genetic condition (familial hypercholesterolemia) and thus harder to treat only by changing lifestyle.

Medical treatments include using specific medications which lower the quantity of cholesterol in the bloodstream. Simvastatin is used for the treatment of primary hypercholesterolemia and mixed dyslipidemia as a dietary food supplement when the response to diet and other non-pharmacological treatments (physical exercise, weight loss) is insufficient. It is also used to treat homozygous familial hypercholesterolemia (homozygous FH) as a complement to diet and other lipid lowering treatments (e.g. LDL apheresis) or if these therapies turn out to be ineffective.

Simvastatin is recommended in cardiovascular prevention to reduce mortality and cardiovascular morbidity in patients suffering from atherosclerotic cardiovascular disease or diabetes mellitus with normal or elevated cholesterol levels, as a complement to other heart-protecting therapies and treatments of other risk factors.

Therapeutic solutions

Medicinal products:

Setorilin - simvastatin 20mg 40mg tablets

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Food supplements: